Plantar fibromatosis (PFI) is a rare disease of the foot. In PFI, one or more slow-growing, benign (non-cancerous) lumps form along the bottom of the foot. The lump(s) enlarge and become swollen. Walking and even bearing weight on the affected foot can be painful.

Plantar fibromatosis (also known as Ledderhose disease) is a rare pathology of the plantar aponeurosis characterized by disordered fibrous tissue and the subsequent formation of nodules. The primary symptoms include one or more slow-growing benign lumps that form along the medial longitudinal arch which usually become painful and swollen. The condition may reduce quality of life and can cause functional disability, leading in some cases to severe impairment.

If you have PFI or are unsure and have symptoms that you may believe are PFI, please fill out the form on the right and our Clinical Research Coordinator will contact you to learn more and see if you are eligible to participate in this study.